New Hope for Treating Alzheimer’s Disease: A Role for FKBP52 Protein

www.sciencedaily.com – March 20, 2012

New research in humans reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic.  This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms.

A study published online March 21 in the Journal of Alzheimer’s Disease, for the first time demonstrates that the FKBP52 protein, discovered by Professor Etienne Baulieu twenty years ago, may prevent hyperphosphorylation of Tau protein, which has been shown to characterise a number of cerebral neurodegenerative diseases, including Alzheimer’s Disease (AD).

This work has been carried out by Professor Baulieu and his research team at the National Institute for Medical Research in France (INSERM) with the support of philanthropists who help the Institut Baulieu, also in France.

Limited research exists on Tau and its role in the development of AD, but it is known that many neurodegenerative diseases are characterised by the deposition of pathological hyperphosphorylated forms of Tau protein, into structures known as ‘Tau tangles.”  The mechanism of Tau toxicity is unclear and there are currently no drug treatments targeting Tau, nor any biomarkers that predict the risk of a future “Tauopathy.”  Professor Baulieu decided to focus on Tau abnormalities and was the first to discover in 2010, an interaction between Tau, and the FKBP52 protein.*

The new research takes his previous research to the next level.  It demonstrates a direct correlation between high levels of hyperphosphorylated Tau protein and reduced levels of FKBP52, in brain cells from patients who have died following AD, compared with normal brain cells.  This suggests that FKBP52 could control the aberrant production of pathogenic Tau.  When FKBP52 is reduced in the nerve cells of AD patients, pathogenic Tau is free to accumulate and contribute to the degeneration of brain cells.

In conclusion, early measurement of FKBP52 levels could form the basis of a predictive test for AD before the onset of clinical symptoms, and new compounds modulating FKBP52′s activity could become the next generation of treatments for the disease.

Commenting on this new research, Professor Baulieu said:

“There is still a worrying lack of research into the causes of age-related brain disorders such as Alzheimer’s Disease and Dementia.  I founded the Institut Baulieu, with the aim of being able to treat and even prevent these diseases.  Research on Tau has been very limited, and until recently, I was among the few scientists focusing on Tau pathology.  The discovery of the FKBP52 protein is the only ‘anti-Tau’ perspective so far.  Its reduced production in the brains of Alzheimer’s patients marks a turning point in understanding this complex disease.  I believe it takes us one step closer to developing an effective treatment and possible predictive tests for the increasing number of people who may develop Alzheimer’s Disease in our ageing societies.”

* A role for FKBP52 in Tau protein function.  Béatrice Chambraud, Elodie Sardin, Julien Giustiniani, Omar Dounane, Michael Schumacher, Michel Goedert, and Etienne-Emile Baulieu, (2010) Proc Nat’l Acad Sci USA, Vol. 107, pp: 2658-2663.

Daily Aspirin ‘Prevents and Possibly Treats Cancer’

By Michelle Roberts, BBC Health Reporter, March 20, 2012 – www.bbc.co.uk/news/health.

Taking a low dose of aspirin every day can prevent and possibly even treat cancer, fresh evidence suggests.

The three new studies published by The Lancet add to mounting evidence of the drug’s anti-cancer effects.

Many people already take daily aspirin as a heart drug.

But experts warn that there is still not enough proof to recommend it to prevent cancer cases and deaths and warn that the drug can cause dangerous side effects like stomach bleeds.

Professor Peter Rothwell, from Oxford University, and colleagues, who carried out the latest work, had already linked aspirin with a lower risk of certain cancers, particularly bowel cancer.

But their previous work suggested people needed to take the drug for about 10 years to get any protection.

Now the same experts believe the protective effect occurs much sooner – within three to five years – based on a new analysis of data from 51 trials involving more than 77,000 patients.

And aspirin appears not only to reduce the risk of developing many different cancers in the first place, but may also stop cancers spreading around the body.

The trials were designed to compare aspirin with no treatment for the prevention of heart disease.

But when Professor Rothwell’s team examined how many of the participants developed and died from cancer, they found this was also related to aspirin use.

Taking a low (75-300mg) daily dose of the drug appeared to cut the total number of cancer cases by about a quarter after only three years – there were nine cancer cases per 1,000 each year in the aspirin-taking group, compared with 12 per 1,000 for those taking dummy pills.

It also reduced the risk of a cancer death by 15% within five years (and sooner if the dose was higher than 300mg).

And if patients stayed on aspirin for longer, their cancer death risk went down even further – by 37% after five years.

Low-dose aspirin also appeared to reduce the likelihood that cancers, particularly bowel, would spread (metastasise) to other parts of the body, and by as much as half in some instances.

In absolute numbers, this could mean for every five patients treated with aspirin one metastatic cancer would be prevented, the researchers estimate.

At the same time, aspirin cut the risk of heart attacks and strokes, but it also increased the risk of a major bleed.

However this elevated bleeding risk was only seen in the first few years of aspirin therapy and decreased after that.

Critics point out that some of the doses given in the study were much higher than the 75mg dose typically given in the UK.  Also, some very large US studies looking at aspirin use were not included in the analysis.  The researchers acknowledge both of these points in their published papers.

Professor Rothwell says for most fit and healthy people, the most important things they can do to reduce their lifetime cancer risk is to give up smoking, take exercise and have a healthy diet.

After that aspirin does seem to reduce the risk further – only by a small amount if there is no risk factor, but if there is a family history for something like colorectal cancer, it tips the balance in favour of aspirin, he said.

Professor Peter Johnson, of Cancer Research UK, said it was still a good idea for people thinking of taking aspirin to discuss it with their Primary Care Physician because of the possible side effects.

But he said the work was exciting and suggested aspirin might be beneficial for treating and preventing cancer, which is something the charity is exploring in its own research.

“We now need some definitive advice from the government as to whether aspirin should be recommended more widely,” he said.

The National Institute for Health and Clinical Excellence (NICE), which issues treatment guidelines for the NHS, has not yet been asked by the government to look at the topic but a spokesman for the Department of Health said they were considering how best to advise the public about the benefits and risks of aspirin.

Meanwhile, the leader of an ongoing UK trial looking at cancers of the gastrointestinal tract said their results – as yet unpublished – suggested no preventative effect of aspirin after following patients for several years.

Professor Janusz Jankowski of Barts and The London School of Medicine and Dentistry said: “So far aspirin cancer prevention effects have not been seen in this major UK study after > 4.5 years of therapy. “

Aspirin

Aspirin (acetylsalicylic acid) has been used for many years as a painkiller.  It has an anti-inflammatory action.  Low-dose (75mg) aspirin is already recommended for people with known cardiovascular disease to prevent stroke and heart attack.  The benefits for healthy people are still unclear.  Aspirin can cause fatal internal bleeding, although this is relatively rare.

Pain Relievers Could Be Spiking Your Blood Pressure

www.sciencedaily.com – March 20, 2012.

Diseases such as kidney failure and endocrine tumors are among the suspects causing high blood pressure – but could the common pain relievers in your medicine cabinet be the culprit?

According to Professor Ehud Grossman of Tel Aviv University’s Sackler Faculty of Medicine and the Sheba Medical Center, many common over-the-counter and prescription medications are underlying causes of hypertension, which is a major risk factor for stroke, heart attack, and aneurisms.  The chemical components of the drugs can raise blood pressure or interfere with anti-hypertensive medications, he explains.  And while many medications can cause this drug-induced hypertension, both patients and doctors remain dangerously uninformed.

His recent research was published in the American Journal of Medicine.

Weighing the treatment options

“In diagnosing the causes of hypertension, over-the-counter drugs like ibuprofen are often overlooked,” says Professor Grossman.  Patients often assume that because a medication can be obtained without a prescription, it’s relatively harmless.  But that’s not always the case.

Many of the medications that are linked with a rise in blood pressure are quite widely used, says Professor Grossman, whose research provides an overview of which medications are related to high blood pressure.  Examples include contraceptive pills, various anti-depressants, anti-inflammatory pills to control pain, and bacterial antibiotics.

Though high blood pressure is a known side effect of many of these medications, doctors do not always account for them in their treatment plans, and they don’t inform patients of the potential risks associated with these medications.  It’s ultimately the doctor’s responsibility to weigh treatment options and present the best course for their patient should issues of hypertension arise, Professor Grossman says.

Doctors may be advised to decrease the dosage of the drug, or add an anti-hypertensive drug to the treatment regime, he says. In any case, awareness on the part of both doctors and patients needs to be raised.  “Many physicians don’t account for this, and some don’t even know about it.  It’s their responsibility to be informed and make sure that their patients are aware that this is a possibility.”

Cost and benefit

Though much of the time a course of treatment can be altered to account for the dangers of hypertension, that isn’t always the case.  For example, new anti-vascular endothelial growth factor drugs, which may increase blood pressure, block the formation of new blood vessels and arteries to solid tumors.  Because the drugs are so effective in treating these malignancies, the benefit outweighs the cost, he believes.

But that doesn’t mean that patients shouldn’t be watched closely for signs of hypertension. “Once a patient has won a longer life with the use of these drugs, you don’t want to expose them to problems associated with blood pressure, such as stroke,” says Professor Grossman.  There are simple ways to counteract drug-induced hypertension, such as the thoughtful addition of anti-hypertensive medications to a treatment plan, he says.

Eyesight ‘Clue’ to Mental Decline

By James Gallagher, BBC Health & Science Reporter, March 15, 2012 – www.bbc.co.uk/news/health.

Looking at the back of the eye may offer an insight into the health of someone’s brain, according to researchers in the United States.

A small study, published in the journal Neurology, linked damage to the retina with declining brain function.

They believe issues with the blood supply may be damaging both the eye and the brain.

Alzheimer’s Research UK said the study showed the importance of a healthy heart.

The eye condition the researchers were looking at was retinopathy, which is common in patients with Type 2 diabetes or high blood pressure.  Damage to the retina can eventually lead to blindness.

Scientists followed 511 women, who were 65 or older, for a decade.  Some 39 were diagnosed with retinopathy.

Those with the eye condition tended to have lower scores in tests of brain function, including memory and abstract reasoning exams.

Brain scans also showed up more areas of damaged brain tissue, ischemic lesions, in those with retinopathy.

Dr. Mary Haan, from the University of California, San Francisco, said:  ”Problems with the tiny blood vessels in the eye may be a sign that there are also problems with the blood vessels in the brain that can lead to cognitive problems.  This could be very useful if simple eye screening could give us an early indication that people might be at risk of problems with their brain health and functioning.”

There was only a small number of patients with retinopathy in the study.  Much larger studies would be needed to see if the findings could be used as a clinical test for declining brain function.

While there was no suggestion of dementia in the patients, brain decline can be an early sign of the disease.

Dr. Simon Ridley, head of research at Alzheimer’s Research UK, said:  ”Accurate early detection of the cognitive decline that can be associated with dementia could unlock our ability to treat it.  This small study offers clues for another possible route doctors could consider when monitoring for the signs of cognitive decline.  The study adds to mounting evidence linking vascular health to cognitive decline, and underlines the importance of looking after our hearts.  It will be useful to see whether the people in this study went on to develop dementia.”

March 24 Seminar: Facing Memory Loss

FACING MEMORY LOSS

“The Importance of a Proper Memory Evaluation and Planning Legal Strategies”

Date:  Saturday, March 24, 2012

Time:  9:30 a.m. (Presentation 10 a.m. to 12:00 p.m.)

Location:  Civic Park Community Center (in the Lounge)

1375 Civic Drive, Walnut Creek, CA

Cost:  FREE!

Refreshments – coffee and sweet rolls – will be served.

Meet Senior Service Providers!

GUEST SPEAKERS:

Dr. Eric Freitag, Psy.D.

Executive Director of the Mt. Diablo Memory Center, 1940 Tice Valley Boulevard, Walnut Creek, CA  94595 (925-988-0569).  Dr. Freitag is a licensed clinical psychologist and neuropsychologist.  His clinical expertise includes assesssment and treatment of dementia, traumatic brain injury and sport concussion.  He is a graduate of the Wright Institute in Berkeley, CA.  Dr. Freitag is a member of the American Psychological Association Division of Neuropsychology, National Academy of Neuropsychology and the International Brain Injury Association.

Michael J. Young, Elder Law Attorney

1931 San Miguel Drive, Walnut Creek, CA  94596, 925-256-0298.  Michael J. Young has been licensed as an attorney in the State of California since 1977.  He has over 20 years of experience in estate planning, probates and trust administration.  Michael is the author of the Alzheimer’s Legal Survival Kit as well as his monthly newsletter entitled Elder Law Today.  He is a member of the National Academy of Elder Law Attorneys.

Please RSVP to Meals on Wheels and Senior Outreach Services at 925-937-8311.

Sponsored by Meals on Wheels and Senior Outreach Services.

Why I Became a Parkinson’s Advocate

By Karen Anderson, The Parkinson’s Perspective Newsletter, Jan/Feb 2012 – www.parkinsonsresources.org.

It has been more than twenty years since my husband Roger was diagnosed with Parkinson’s disease.  We were young then (Roger was only 47) and took the original diagnosis in stride like we had so many other adverse events in our life.  We had the attitude that together we could conquer anything and Parkinson’s Disease (PD) was just a bump along the way.

But a couple of years ago Roger experienced a series of “health events” that shook us both to the core and caused us to reevaluate our plans and the roles we have to play in making things better.

Ironically, the problems initially had nothing to do with PD.  Roger needed surgery for a herniated disc – it should have been a fairly straightforward procedure.  However, infection and disc disintegration led to a total of 5 back surgeries and 90+ days spent in either a hospital, skilled nursing facility or a rehabilitation center.  Needless to say, we have had our fill of hospitals, emergency rooms, ambulance rides, nursing homes and rehabilitation centers!

The months leading up to the first surgery were exhausting for both of us as Roger’s care needs were increasing due to his pain and impaired mobility.  We knew there was always a risk associated with surgery and wanted to make sure the procedure was entirely necessary before committing to the plan.  I remember thinking that at least when he was at the hospital I would have a rest because medical professionals would be caring for him.

I couldn’t have been more WRONG.  I still found myself a full-time caregiver, only in the hospital I had very little authority.  I had heard from folks at my support group that people sometimes had a hard time getting medication on time but I didn’t believe it would happen to us!  It was after the 2nd surgery that reality set in.  I spent 24 hours a day with Roger in the hospital for 4 days and found that I had to go over his medication schedule and medications with every shift nurse.  He rarely got his meds on time, and when he did, it was because I was pro-active and started looking for a nurse an hour before it was time for the next dose.  After histhird surgery, Roger went to a Skilled Nursing Facility for rehab – the idea being to get him back to walking before he came home again.  What no one there seemed to understand was that when they were late getting his meds to him, he could not participate in physical therapy or feed himself.  Again, I was with him all the time making sure his meds were okay and given to him on time.  It was a horrible nightmare that I could not wake up from, here I was the distraught spouse trying to fight for my husband’s life – and I had to constantly find ways to care for him.

Roger’s mother was with me during the last 6 weeks of his hospital stays and finally one day she looked at me and asked “why can’t they get his Parkinson’s medication right?”  I wasn’t able to give her an answer.

Eventually Roger recovered and was able to regain his ability to walk and take care of his personal needs.  I am convinced his recovery would have been much quicker had the entire medical team each step of the way understood PD just a little bit better.  It is no exaggeration to say that what I fear most is another unexpected hospitalization.  I hope and pray no other caregiver or PD patient has to endure this kind of pain and suffering.  All I ever wanted was for Roger to receive the best medical care available.  If it was your husband or wife, I’m sure you would want the same.

As this experience grows further in our past, I remain a staunch advocate for ALL people with PD receiving quality, personalized care.  I’ve taken my message to Washington, D.C., the State Capitol and support any effort to provide education on the importance of meds on time.

As a person with PD or a family caregiver you, too, have a role to play in advocating for your own quality care.  Call Parkinson’s Resources Organization at 1-800-426-6808 for a copy of their Critical Care Information form and be sure to sign up for an Aware In Care presentation when they come to your support group or community.  Arm yourself with information.  The life you change just be might be your own.

April 1: Town Hall Meeting for People Impacted by Parkinson’s Disease

Sunday, April 1, 2012

2:30 to 5:00 p.m.

Berkeley Unitarian Fellowship Hall

1924 Cedar (at Bonita), Berkeley, CA

Sponsored by PD Active!

A community-wide discussion!  For everyone with PD, their caregivers, family and friends.

PD Active! invites anyone concerned with Parkinson’s Disease (PD) to join a discussion about how we can strengthen our Oakland/Berkeley region’s PD community and empower people impacted by PD.  We’ll begin with refreshments and schmoozing; the discussion will begin at 3:00 p.m. and there will be a special performance by The Tremolos, PD Active!’s chorus.  Come prepared to have fun and make new connections!

PD Active! exists to improve quality of life for people affected by PD.  We get involved in creating and improving programs that support and care for people with PD, our families and caregivers.  We believe that we are our own best advocates, and that acting on our own behalf fosters independence, dignity and respect while preventing isolation and depression.

PD Active! | P.O. Box 22923, Oakland, CA  94609 | 1-510-479-6119 | info@pdactive.org | www.pdactive.org.

Coming Clean About First Colonoscopy

By Lisa O’Neill Hill, www.cnn.com/health – March 6, 2012.

In my 20s, after my doctor performed a laparoscopy to examine my uterus and ovaries, he gave me a videotape of the procedure.  I dubbed it “Madame Ovary,” threw a party and screened it for my friends.

Three years ago, when my doctor sent me to have a colonoscopy, the last thing on my mind was seeing footage from the exam.

At 39, I was mortified about having a procedure that I associated with older people.  I didn’t even want to talk about it, let alone see it.

But March is National Colorectal Cancer Awareness Month, so I’m coming clean.  While drinking two liters of liquid that tastes like dirty sea water to evacuate my bowels doesn’t rank highly on my list of things to do, neither does dying from colon cancer.  And having a colonoscopy, although unpleasant and embarrassing, was one of the best things I have ever done for my health.

Of all cancers affecting both men and women, colorectal cancer — cancer of the colon or rectum — is the second-leading killer in the United States, according to the Centers for Disease Control and Prevention.

Overall, the lifetime risk of developing colorectal cancer is 1 in 20, and up to 150,000 new cases a year are reported in the United States, the American Cancer Society says.  A recent study published in the New England Journal of Medicine found that removing precancerous growths spotted during a colonoscopy can cut the risk of dying from colon cancer in half.  More than 95% of tumors are detected during a colonoscopy.

Yet despite these statistics, people feel squeamish about the exam and tend to put it off.

“It’s a potentially embarrassing procedure.  It’s not like an eye exam in terms of personal exposure,” said Dr. Anthony N. Kalloo, the director of gastroenterology and hepatology at The Johns Hopkins Hospital.

The American Cancer Society and the American College of Physicians recommend that adults be screened for colorectal cancer starting at age 50.  Doctors urge people with a family history of colon cancer to begin screening much earlier.

I guess I’m an overachiever.  While I don’t have a family history of that kind of cancer, I did have one of the common symptoms — bleeding, a change in bowel habits, weight loss, poor appetite, bloating and/or abdominal pain — that sent me running to my family doctor.  He referred me to St. Jude’s Knott Family Endoscopy Center in Fullerton, California, for a colonoscopy.

I can’t describe the pure joy I felt at receiving THAT news.

I didn’t know too much about the procedure but what I did know sounded horrible.  During a colonoscopy, a doctor examines the inside of the colon and rectum by inserting a colonoscope, a thin, flexible instrument that sends images to a TV screen or computer.

In order for the doctor to do a thorough exam, the patient needs to prepare by fasting;  I drank only liquids the day before the exam.  He or she may also be required to chug down a solution that will … let’s just say keep them at home, near a bathroom.

“It literally takes a whole day away from your life, where you could be doing normal things and instead you are drinking this bowel prep that is uncomfortable and that limits your social life,” Kalloo said.

Following the instructions I was given, I started fasting the day before the procedure.  I was restricted to certain fluids and particular colors of Jell-O (nothing red or purple.)  I spent the morning longing for my usual massive cup of coffee and substantial breakfast and instead downed water, Gatorade and chicken broth.

Around 5 p.m., the fun really started.  I began drinking a liter of a polyethylene glycol (PEG) bowel prep.  I had to down 8 ounces of this stuff every 15 minutes followed by 16 ounces of clear liquid.  I drank another liter several hours later while trying not to vomit.

The manufacturers said the solution was lemon-flavored; it really resembled a noxious mix of chemicals that I can still taste to this day.

Dr. Gene Yoon, my gastroenterologist, concedes that for most patients, the preparation is the worst part.  Yoon and other physicians now use magnesium citrate, which he said requires patients to drink less, is easier to tolerate and works just as well.

By the time I arrived at the Knott Family Endoscopy Center the next morning, I was nervous and praying the worst was over.  It was.  I don’t remember anything past the point where I was sedated.  An IV solution sent me into a “twilight sleep.”  It also made me forget the procedure, which no doubt was for the best.

When I woke up, I was groggy but I also felt incredibly well rested.  I had only a small amount of discomfort, including abdominal cramping that doctors say is normal.

I don’t remember getting dressed or leaving the hospital.  But in my daze, I asked my father to swing by Starbucks to pick up a cup of coffee and a sandwich.  When I got home, I dozed for a few hours and that was that.

Yoon called the next day with my results:  He’d found and removed a 1.5 centimeter villous adenoma polyp from my sigmoid colon.  After examining the polyp, Yoon estimated that there was a more than a 50% chance of that polyp becoming malignant.

Yoon removed the polyp before that had a chance of happening.  Of all the polyps, villous adenomas are associated with the highest mortality and morbidity rate.

I consider myself extremely lucky I had a symptom.  If I hadn’t, I wouldn’t have had a colonoscopy until I was at least 50 — and who knows how long I would have put it off after that.

“Colon cancer is one of the few cancers that can actually be prevented, mainly because it goes through this polyp stage before it turns into colon cancer,” Yoon says.

Given what he’d found, Yoon suggested that my younger brother also have a colonoscopy.  Craig had his colonoscopy when he was 36; the doctors didn’t find anything.

Two important people in my life, my husband’s stepfather and my trainer, have had colon cancer.  For both of them, the cancer was detected during routine colonoscopies.  I thank God they were proactive about their health.

Polyps are slow-growing and asymptomatic, Yoon says.  The cancer can also be slow-growing and asymptomatic — until it starts spreading.

“Usually once you start developing symptoms from colon cancer, things are way too late,” he said.

Eating a high-fat diet, consuming red meat and smoking will increase your risk of developing colorectal cancer, as is a familial history of the disease.  Doctors recommend exercising and eating a diet rich in vegetables, fruit and fiber.

At Hopkins, researchers are looking into the role that cumin – a spice commonly used in India – may play in reducing the risk of colon cancer.  Preclinical and laboratory tests show it may be useful, Kalloo said.  I’ve always loved curry, and I’m thinking about ways to incorporate this spice into our meals.

But even if you play by the rules of healthy living, it’s important to get screened.

“We have to do better,” Kalloo says.  “Family care physicians and everyone who sees patients should ask someone over 50, ‘Have you had a colonoscopy?’  It’s just not a convenient test.  Even physicians tend to procrastinate.”

After Yoon called me with the results, I sent a thank you note to my family doctor, telling him how much I appreciated him referring me for a colonoscopy.  Yoon’s office called me recently to set up another appointment.  I’m not looking forward to it, but there’s no question I will do it again.

Considering the alternative, I’d be crazy not to.

Alzheimer’s Patients ‘Should Stay on Drugs for Longer’

By Jane Draeper, BBC Health Correspondent, March 7, 2012 – www.bbc.co.uk/news/health.

Thousands of patients with advanced Alzheimer’s Disease (AD) could benefit from drugs, research suggests.

A study in the the New England Journal of Medicine found that patients who stayed on the dementia drug Aricept had a slower decline in their memory.

The drug tends not to be prescribed once sufferers progress beyond moderate symptoms.

Medicines regulator NICE said its guidelines supported continuing treatment where there were benefits.

The patent for the medicine Aricept, which is used to treat AD, expired recently.  Much cheaper versions under the generic name donepezil are already available for about £12 ($20) a month.

The researchers say their new evidence could lead to twice as many AD sufferers worldwide being given medication.

The trial involved 295 AD patients in England and Scotland who had been taking Aricept.

One set were given placebo tablets while another set stayed on Aricept.  A third set were given another drug, Ebixa, or memantine, which is usually prescribed only in the later stages of AD.

The fourth batch of patients received a combination of both drugs.

The researchers assessed each group for a year, looking at their cognitive scores on factors like memory, and also at how well they coped with everyday tasks such as dressing and eating.

The drugs were unable to halt the decline of patients, but they slowed it down.

The study’s lead author, Professor Robert Howard from King’s College London Institute of Psychiatry, said:  ”For the first time, we have robust and compelling evidence that treatment with these drugs can continue to help patients at the more severe stages.

“Patients who continued taking donepezil were about four months ahead in how they were able to remember, communicate and perform daily tasks than those who stopped taking the drugs.

“It means a lot to doctors and carers to see differences like that.  These improvements were sustained throughout the year.  It’s fair to say that both drugs have independent, positive effects at this stage of dementia.  I’m advising hospital colleagues to continue patients on donepezil, when it’s tolerated, and to add in memantine.”

About 500,000 people in the UK are thought to have AD – with only about 10% who are in the earlier stages currently on drug treatment.

NHS funding of dementia drugs has been controversial in the past.  The National Institute for Health and Clinical Excellence (NICE) set restrictions in 2006, which campaigners tried to overturn in court.

A year ago, revised NICE guidelines accepted that medicines including Aricept were cost-effective and could be prescribed earlier in the course of the disease.

Professor Clive Ballard from the Alzheimer’s Society, which part-funded the trial alongside the Medical Research Council, said:  ”Usual practice has been to discontinue the treatment once patients have declined to a certain stage.  This trial suggests the default position should be the other way round, because most people are benefiting.  It’s not so much the NICE guidance that needs to change – but how clinicians interpret it.”

NICE said its guidelines did not include any specific recommendations on when to discontinue medicines.

Dr. Simon Ridley from Alzheimer’s Research UK said:  “Trials such as this are extremely important for informing decisions about the way medication is prescribed.  It would be helpful to see longer-term trials to determine exactly how long the benefits seen in this study might last.  Sadly we still lack a treatment that can stop Alzheimer’s disease in its tracks.”

Three Quick Tax Tips for People with Parkinson’s and/or other Disabilities

Source:  Allsup, Inc. – www.allsup.com | www.youngparkinsons.org/articles/tax-preparation.

Your life may be very different since you were diagnosed with Parkinson’s Disease (PD).  As your life changes, so do your taxes.   These quick tips will provide information on determining if you qualify for additional tax credits, getting free help with your taxes through the Volunteer Income Tax Assistance, and calculating the taxes on your lump-sum retroactive award.

Tip 1:  Even if your income is low, it’s usually a good idea to file a tax return.

If your income is low, the IRS may not require you to file a tax return.  But file anyway.  Even though you don’t owe money to the IRS, the IRS may owe you money.  Did you or your spouse work at any point during 2011?  Were income taxes withheld from your paycheck?  If so, the IRS might owe you a tax refund.  But you won’t get a refund if you don’t file a return.  The same goes for state income taxes.  If you or your spouse had any state income taxes withheld from a paycheck in 2011, file a state income tax return to see if you get a refund.  Here’s a key reason to file a tax return.  It’s called the Earned Income Tax Credit (EITC), and it can be a big help if you qualify.  The EITC helps low-income individuals and families.  If you or your spouse earned any taxable income during the year, you may qualify if the amount you earned is less than the earnings level set by the government.  Click here to see what earnings qualify in 2011 and to learn about other tax credits for people with lower incomes.  It’s possible with the EITC to get back more money than you actually paid in taxes.  You don’t want to miss out on this much-needed cash, so file a return if you think you may qualify.  Many states also offer an Earned Income Tax Credit.  That’s another good reason to file a state return in addition to your federal return.

Tip 2:  You can get free help with your taxes.

The IRS has a Volunteer Income Tax Assistance (VITA) program to help people with low or moderate incomes file their taxes.  Trained volunteers can help you prepare your return.  They will check to see if you qualify for the EITC and other tax credits and deductions so you can get the refund you are entitled to.  There are more that 12,000 VITA sites across the United States.  You’ll find VITA sites in community and neighborhood centers, libraries, schools, shopping malls and other convenient places.  Call the IRS at 1-800-906-9887 to find a location near you.  Click here for information about other ways you can get free or low-cost help with your taxes.

Tip 3:  If you received your Social Security disability award in 2011, get help to figure out the taxes on your lump-sum retroactive award.

It’s very complicated to calculate the taxes on a lump-sum payment and not something you want to do yourself.  The last thing you need is to pay more tax on your lump sum than you owe.  An experienced tax preparer can help you with your taxes in the year you receive your lump-sum payment.  You may still qualify for free tax help.  But, for this one year, you could actually save money by hiring a knowledgeable professional who can help you pay the correct amount of tax on your lump sum.  Find a tax preparer with experience doing taxes for people with disabilities.  When you call a tax preparer, ask to talk to someone who knows about taxes and Social Security disability.  Not all tax preparers understand how to do taxes on a lump-sum payment.  At the very least, make sure your tax preparer is familiar with the disability information in IRS Publication 915.

It’s no fun doing your taxes.  But you’ll be glad you made the effort if you get some refund money for your trouble!

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